2006 Steelers 23 at Bengals 17 OT
Santonio Holmes 67-yd TD catch-and-run in overtime ends the Bengals season (no playoffs for you!) and sends Coach Cowher out on a high note in his final game as head coach of the Steelers. The defending Super Bowl champion Steelers are already eliminated from playoff contention coming into the game, but the Bengals were still in position to clinch a Wild Card berth with a win.
Instead, the Steelers play spoiler as the Bungles miss a 39-yd FG attempt with 8 seconds left in regulation and Big Ben needs just 3 plays in overtime to hit Holmes in stride on a slant. Santonio does the rest, eluding multiple defenders as he sprints down the sideline and finally dives the final few yards into the end zone for the 67-yd game winner.